SS-31/
D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2,6-dimethyl-L-tyrosine)
Sheet
- Molecular Weight
- 639.80 g/mol
- Molecular Formula
- C₃₂H₄₉N₉O₅
- CAS
- 736992-21-5
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
Cardiolipin Binding
Mitochondrial Targeting
Redox Research
SS-31 (elamipretide) is a synthetic mitochondria-targeting tetrapeptide. In published research, SS-31 was reported to associate with cardiolipin on the inner mitochondrial membrane and to re-energize ischemic mitochondria in cell and tissue models (Birk et al, 2013, PMID 23813215).
In a separate study, the mitochondrially-targeted tetrapeptide elamipretide was examined for neuroprotective effects in models of neurodegeneration (Nhu et al, 2021, PMID 35111001). SS-31 is characterized in the literature as an aromatic-cationic peptide that concentrates in mitochondria. For research purposes only.
Questions
SS-31 (elamipretide) is a synthetic mitochondria-targeting tetrapeptide. In published research, SS-31 was reported to associate with cardiolipin on the inner mitochondrial membrane and to re-energize ischemic mitochondria in cell and tissue models (Birk et al, 2013, PMID 23813215). Referenced for mechanism only; for research purposes only.