5-Amino-1MQ/
Sheet
- Molecular Weight
- 159.21 g/mol (free base)
- Molecular Formula
- C₁₀H₁₁N₂ (free base)
- CAS
- 42464-96-0
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
NNMT Inhibition
1-Methylquinolinium Scaffold
NAD⁺ Metabolism Research
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium studied in published research as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and sits at the intersection of NAD⁺ metabolism and cellular methylation (Sun et al, 2024, PMID 38919254).
In foundational work on the target, genetic knockdown of NNMT was reported to alter metabolic phenotypes in a rodent model of diet-induced obesity (Kraus et al, 2014, PMID 24717514). 5-Amino-1MQ is studied as a pharmacological probe of the NNMT pathway. For research purposes only.
Questions
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule quinolinium studied in published research as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide and sits at the intersection of NAD⁺ metabolism and cellular methylation (Sun et al, 2024, PMID 38919254). Referenced for mechanism only; for research purposes only.