PE-22-28/
Gly-Val-Ser-Trp-Gly-Leu-Arg · GVSWGLR
Sheet
- Molecular Weight
- 773.89 g/mol
- Molecular Formula
- C₃₅H₅₅N₁₁O₉
- CAS
- 1801959-12-5
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
TREK-1 Channel Inhibition
Sortilin-Derived Peptide
Spadin Fragment
PE-22-28 is a shortened seven-residue analog of spadin, a peptide derived from the propeptide of sortilin (neurotensin receptor 3). In published research, spadin and its shortened analogs were characterized as inhibitors of the TREK-1 two-pore-domain potassium channel in rodent models (Djillani et al, 2017, PMID 28955242).
In earlier work, spadin was described as a sortilin-derived peptide targeting rodent TREK-1 channels, framed by the authors as a concept in antidepressant drug design (Mazella et al, 2010, PMID 20405001). PE-22-28 corresponds to the C-terminal fragment of that parent sequence and is studied for its TREK-1 binding profile. For research purposes only.
Citations
- [01]Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity.↗
- [02]Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design.↗
Literature citations verified against PubMed: 2026-07-11.
Questions
PE-22-28 is a shortened seven-residue analog of spadin, a peptide derived from the propeptide of sortilin (neurotensin receptor 3). In published research, spadin and its shortened analogs were characterized as inhibitors of the TREK-1 two-pore-domain potassium channel in rodent models (Djillani et al, 2017, PMID 28955242). Referenced for mechanism only; for research purposes only.