N-Acetyl Selank/
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro · Ac-TKPRPGP
Sheet
- Molecular Weight
- 793.92 g/mol
- Molecular Formula
- C₃₅H₅₉N₁₁O₁₀
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
N-Terminal Acetylation
Tuftsin-Analog Signaling
BDNF Regulation
N-Acetyl Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide based on the endogenous immunomodulatory peptide tuftsin. N-terminal acetylation is a backbone modification studied for peptide stability. In published research on the parent peptide, Selank was shown to regulate brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex of rats (Kolik et al, 2019, PMID 31625062).
In a separate rat study, the parent peptide Selank attenuated aversive signs associated with morphine withdrawal (Konstantinopolsky et al, 2022, PMID 36322304). N-Acetyl Selank shares the tuftsin-analog sequence of Selank with an acetylated N-terminus. For research purposes only.
Citations
- [01]Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.↗
- [02]Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.↗
Literature citations verified against PubMed: 2026-07-11.
Questions
N-Acetyl Selank is the N-terminally acetylated analog of Selank, a synthetic heptapeptide based on the endogenous immunomodulatory peptide tuftsin. N-terminal acetylation is a backbone modification studied for peptide stability. In published research on the parent peptide, Selank was shown to regulate brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex of rats (Kolik et al, 2019, PMID 31625062). Referenced for mechanism only; for research purposes only.