N-Acetyl Semax/
Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂ · Ac-MEHFPGP-NH₂
Sheet
- Molecular Weight
- 855.00 g/mol
- Molecular Formula
- C₃₉H₅₄N₁₀O₁₀S
- CAS
- 2920938-90-3
- Form
- N-acetyl · C-terminal amidate
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
N-Terminal Acetylation
C-Terminal Amidation
BDNF Neurotrophic Signaling
N-Acetyl Semax is a terminally modified analog of Semax, itself a synthetic heptapeptide analog of adrenocorticotropin fragment 4-10. The common form carries an acetylated N-terminus and an amidated C-terminus, modifications studied for peptide stability. In published research on the parent peptide, Semax was shown to bind specifically and increase brain-derived neurotrophic factor (BDNF) protein levels in the rat basal forebrain (Dolotov et al, 2006, PMID 16635254).
A later study examined Semax and a derivative in an animal model of Alzheimer-type pathology (Radchenko et al, 2025, PMID 41479572). N-Acetyl Semax shares the ACTH(4-10) core sequence of Semax with acetyl and amide terminal modifications. For research purposes only.
Citations
- [01]Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.↗
- [02]The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease.↗
Literature citations verified against PubMed: 2026-07-11.
Questions
N-Acetyl Semax is a terminally modified analog of Semax, itself a synthetic heptapeptide analog of adrenocorticotropin fragment 4-10. The common form carries an acetylated N-terminus and an amidated C-terminus, modifications studied for peptide stability. In published research on the parent peptide, Semax was shown to bind specifically and increase brain-derived neurotrophic factor (BDNF) protein levels in the rat basal forebrain (Dolotov et al, 2006, PMID 16635254). Referenced for mechanism only; for research purposes only.