Noopept/
Sheet
- Molecular Weight
- 318.37 g/mol
- Molecular Formula
- C₁₇H₂₂N₂O₄
- CAS
- 157115-85-0
- Assayed Purity
- ≥ 98.0% (release spec)
- Source
- Domestic · 3rd-party verified
- Storage
- -20°C lyophilized
Mechanism
NGF & BDNF Modulation
Proline-Containing Dipeptide
GluA1 AMPA Receptor
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic proline-containing dipeptide. In published research, Noopept was reported to increase nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat hippocampus (Ostrovskaya et al, 2008, PMID 18693743).
In a separate study examining mechanism of action, Noopept was shown to potentiate GluA1-containing AMPA receptors in isolated rat hippocampal neurons (Borzova et al, 2015, PMID 26199225). The compound is structurally related to the endogenous cyclic dipeptide cycloprolylglycine.
Citations
- [01]Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.↗
- [02]The dipeptide Noopept potentiates different AMPA receptors in isolated rat hippocampal neurons.↗
Literature citations verified against PubMed: 2026-07-11.
Questions
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic proline-containing dipeptide. In published research, Noopept was reported to increase nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat hippocampus (Ostrovskaya et al, 2008, PMID 18693743). Referenced for mechanism only; for research purposes only.